This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene has shortened LRR and ubiquitin-associated domains and its RDB is unable to bind RNA. It is located in the nucleoplasm but is not associated with either the nuclear envelope or the nucleolus. [provided by RefSeq, Jul 2008]
Function:
May function as a tissue-specific nuclear mRNA export factor.
Subcellular Location:
Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm.
Tissue Specificity:
Expressed at high level in testis and at low level in a small number of tissues.
Similarity:
Belongs to the NXF family.
Contains 1 NTF2 domain.
Contains 1 RRM (RNA recognition motif) domain.
SWISS:
Q9H4D5
Gene ID:
56000
Database links:
Entrez Gene: 56000 Human
Omim: 300316 Human
SwissProt: Q9H4D5 Human
Unigene: 60386 Human
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