The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in both RAN (Ras-related nuclear protein)- and CRM1 (required for chromosome region maintenance)-dependent pathways. It is found to stimulate the export of U1 snRNA in RAN- and CRM1-dependent pathways and the export of tRNA and mRNA in a CRM1-independent pathway. The encoded protein heterodimerizes with Tap protein and may regulate the ability of Tap protein to mediate nuclear mRNA export. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
Function:
Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with THOC4 and THOC5.
Subcellular Location:
Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm.
Similarity:
Contains 1 NTF2 domain.
SWISS:
Q9UKK6
Gene ID:
29107
Database links:
Entrez Gene: 29107 Human
Entrez Gene: 520351 Cow
Entrez Gene: 56488 Mouse
Entrez Gene: 296219 Rat
Omim: 605811 Human
SwissProt: Q2KIW0 Cow
SwissProt: Q9UKK6 Human
SwissProt: Q9QZV9 Mouse
Unigene: 516933 Human
Unigene: 34663 Mouse
Unigene: 8541 Rat
|
|
