OSFC1 and C17ORF68 (MIM 613129) are subunits of an alpha accessory factor (AAF) that stimulates the activity of DNA polymerase-alpha-primase (see MIM 176636), the enzyme that initiates DNA replication (Casteel et al., 2009 [PubMed 19119139]). OSFC1 also appears to function in a telomere-associated complex with C17ORF68 and TEN1 (C17ORF106; MIM 613130) (Miyake et al., 2009 [PubMed 19854130]).[supplied by OMIM, Nov 2009]
Function:
Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites.
Subcellular Location:
Nucleus. Chromosome > telomere.
Similarity:
Belongs to the STN1 family.
Contains 1 OB DNA-binding domain.
SWISS:
Q9H668
Gene ID:
79991
Database links:
Entrez Gene: 79991 Human
Entrez Gene: 108689 Mouse
Omim: 613128 Human
SwissProt: Q9H668 Human
SwissProt: Q8K2X3 Mouse
Unigene: 62314 Human
Unigene: 23648 Mouse
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