Single-stranded DNA (ssDNA)-binding proteins, such as OSFC2A, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008]
Function:
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.
Subunit:
Component of the SOSS complex, composed of SOSS-B (SOSS-B1/NABP2 or SOSS-B2/NABP1), SOSS-A/INTS3 and SOSS-C/INIP. SOSS complexes containing SOSS-B1/NABP2 are more abundant than complexes containing SOSS-B2/NABP1. {ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501}.
Subcellular Location:
Nucleus. Localizes to nuclear foci following DNA damage.
Similarity:
Belongs to the SOSS-B family. SOSS-B2 subfamily.
Contains 1 OB DNA-binding domain.
SWISS:
Q96AH0
Gene ID:
64859
Database links:
Entrez Gene: 64859 Human
Entrez Gene: 109019 Mouse
Entrez Gene: 363227 Rat
Omim: 612103 Human
SwissProt: Q96AH0 Human
SwissProt: Q8BGW5 Mouse
SwissProt: Q5FVP2 Rat
Unigene: 591610 Human
Unigene: 196290 Mouse
Unigene: 21433 Rat
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