lymphocyte antigen 6 complex locus protein G6f is a single-pass type I membrane protein belonging to the immunoglobulin (Ig) superfamily. Located in the class III region of the major histocompatibility complex (MHC), the G6f gene lies in a cluster of genes encoding cell-surface proteins that play a role in the immune system and cellular recognition. G6f functions as a downstream effector of GRB2 and GRB7, and, in humans, it interacts with GRB2 and GRB7 through the phosphorylation of a tyrosine residue (Tyr 281) in the intracellular tail of G6f. This interaction is also mediated by the SH2 domain of GRB2 and possibly that of GRB7. G6f is a 297 amino acid protein, and it forms a disulfide-linked homodimer.
Function:
May play a role in the downstream signal transduction pathways involving GRB2 and GRB7.
Subcellular Location:
Cell membrane.
Post-translational modifications:
modificationsN-glycosylated.
Similarity:
Contains 1 Ig-like SLVtype (immunoglobulin-like) domain.
SWISS:
Q6MG56
Gene ID:
309609
Database links:
Entrez Gene: 259215 Human
Entrez Gene: 309609 Rat
Entrez Gene: 433099 Mouse
Omim: 611404 Human
SwissProt: Q5SQ64 Human
SwissProt: Q7Z5H2 Human
SwissProt: Q6MG56 Rat
Unigene: 591794 Human
Unigene: 145028 Rat
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