Home > Product > Antibody > Rabbit Anti-OSFC2B antibody
2610036N15Rik; hSSB1; LP3587; MGC125161; MGC2731; MGC30353; Nabp2; SOSB1_HUMAN; Nucleic acid binding protein 2; Oligonucleotide/oligosaccharide binding fold containing 2B; Oligonucleotide/oligosaccharide binding fold containing protein 2B; RGD13
Cat:
SL19571R
Species Reactivity:
(predicted: Human,Mouse,Rat,Cow,)
Immunogen:
KLH conjugated synthetic peptide derived from human OBFC2B:131-211/211
Format:
Liquid
Storage instructions:
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Concentration:
1mg/ml
Clonality:
Polyclonal
Isotype:
IgG
Applications:
IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500(Paraffin sections need to do antigen repair)not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host:
Rabbit
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Unit:
Price: $
Product PDFs
Datasheet:


Single-stranded DNA (ssDNA)-binding proteins, such as OSFC2B, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008]

Function:
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.

Subunit:
Component of the SOSS complex, composed of SOSS-B (SOSS-B1/NABP2 or SOSS-B2/NABP1), SOSS-A/INTS3 and SOSS-C/INIP. SOSS complexes containing SOSS-B1/NABP2 are more abundant than complexes containing SOSS-B2/NABP1. Directly interacts with ATM, SOSS-A/INTS3 and RAD51. Interacts with INTS7.

Subcellular Location:
Nuclear. Localizes to nuclear foci following DNA damage.

Post-translational modifications:
Phosphorylated by ATM in response to DNA damage. Phosphorylation prevents degradation by the proteasome, hence stabilization of the protein and accumulation within cells.

Similarity:
Belongs to the SOSS-B family. SOSS-B1 subfamily.
Contains 1 OB DNA-binding domain.

SWISS:
Q9BQ15

Gene ID:
79035

Database links:

Entrez Gene: 79035 Human

Entrez Gene: 69917 Mouse

Entrez Gene: 362813 Rat

Omim: 612104 Human

SwissProt: Q9BQ15 Human

SwissProt: Q8R2Y9 Mouse

SwissProt: Q3SWT1 Rat



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