This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009]
Function:
Seems to act on Cbl. May play a role in regulating the function of Cbl and its associated protein kinases. Acts as negative regulator of T cell receptor (TCR) signaling. Dephosphorylates and inactivates the SRC family kinases.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Predominantly expressed in lymphoid tissues and cells. Isoform 1 is expressed in thymocytes and both mature B and T-cells.
Post-translational modifications:
Phosphorylation on Ser-35 by PKC/PRKCD abrogates its ability to dephosphorylate and inactivate the SRC family kinases.
Similarity:
Belongs to the protein-tyrosine phosphatase family.
Non-receptor class 4 subfamily.
Contains 1 tyrosine-protein phosphatase domain.
SWISS:
Q9Y2R2
Gene ID:
26191
Database links:
Entrez Gene: 483124 Dog
Entrez Gene: 100717611 Guinea pig
Entrez Gene: 100059247 Horse
Entrez Gene: 26191 Human
Entrez Gene: 19260 Mouse
Entrez Gene: 295338 Rat
Omim: 600716 Human
SwissProt: Q9Y2R2 Human
SwissProt: P29352 Mouse
Unigene: 535276 Human
Unigene: 395 Mouse
Unigene: 22891 Rat
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