Rabbit Anti-PTPRN2 antibody

Home > Product > Antibody > Rabbit Anti-PTPRN2 antibody

IA 2beta; IA2beta; IAR; IAR/receptor like protein tyrosine phosphatase; ICAAR; Islet cell autoantigen related protein; Islet cell autoantigen-related protein; Phogrin; Protein tyrosine phosphatase receptor pi; Protein tyrosine phosphatase, recept

Cat:

SL19591R

Species Reactivity：

(predicted: Human,)

Immunogen：

KLH conjugated synthetic peptide derived from human PTPRN2:101-200/1015<Extracellular>

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

prev next

Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus. Three alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

Function:
Implicated in development of nervous system and pancreatic endocrine cells.

Subcellular Location:
Membrane.

Tissue Specificity:
Highest levels in brain and pancreas. Lower levels in trachea, prostate, stomach and spinal chord.

Post-translational modifications:
Appears to undergo multiple proteolytic cleavage at consecutive basic residues.

Similarity:
Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily. Contains 1 tyrosine-protein phosphatase domain.

SWISS:
Q92932

Gene ID:
5799

Database links:

Entrez Gene: 5799 Human

Entrez Gene: 19276 Mouse

Entrez Gene: 29714 Rat

Omim: 601698 Human

SwissProt: Q92932 Human

SwissProt: P80560 Mouse

SwissProt: Q63475 Rat

Unigene: 490789 Human

Unigene: 206054 Mouse

Unigene: 11044 Rat

Product Feedback Wall