SDS3 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003 [PubMed 1272884]).[supplied by OMIM, Mar 2008]
Function:
Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways (By similarity). May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.
Tissue Specificity:
Expressed in various cancer cell ines.
Similarity:
Belongs to the SDS3 family.
SWISS:
Q9H7L9
Gene ID:
64426
Database links:
Entrez Gene: 64426 Human
Entrez Gene: 71954 Mouse
Entrez Gene: 445099 Zebrafish
Omim: 608250 Human
SwissProt: Q9H7L9 Human
SwissProt: Q8BR65 Mouse
Unigene: 416630 Human
Unigene: 602312 Human
Unigene: 34456 Mouse
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