The protein encoded by this gene belongs to the SEC13 family of WD-repeat proteins. It is a constituent of the endoplasmic reticulum and the nuclear pore complex. It has similarity to the yeast SEC13 protein, which is required for vesicle biogenesis from endoplasmic reticulum during the transport of proteins. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Oct 2008]
Function:
Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles.
Subunit:
At the nuclear pore: component of the Y-shaped Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex includes NUP160, NUP133, NUP107, NUP98, NUP85, NUP43, NUP37, SEH1 and SEC13. At the COPII coat complex: interacts with SEC31A and SEC31B. Within the GATOR complex, component of the GATOR2 subcomplex, made of MIOS, SEC13, SEH1L, WDR24 and WDR59. The GATOR complex strongly interacts with RRAGA/RRAGC and RRAGB/RRAGC heterodimers.
Subcellular Location:
Cytoplasmic vesicle; COPII-coated vesicle membrane. Endoplasmic reticulum membrane. Nucleus; nuclear pore complex. In interphase, localizes at both sides of the NPC.
Similarity:
Belongs to the WD repeat SEC13 family.
Contains 6 WD repeats.
SWISS:
P55735
Gene ID:
6396
Database links:
Entrez Gene: 6396 Human
Entrez Gene: 92167 Chimpanzee
Entrez Gene: 607653 Dog
Entrez Gene: 101153194 Gorilla
Entrez Gene: 110379 Mouse
Entrez Gene: 100451553 Orangutan
Entrez Gene: 697339 Rhesus monkey
Omim: 600152 Human
SwissProt: P55735 Human
SwissProt: Q9D1M0 Mouse
Unigene: 166924 Human
Unigene: 29296 Mouse
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