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Rabbit Anti-SEC16A antibody
This gene encodes a protein that forms part of the Sec16 complex. This protein has a role in protein transport from the endoplasmic reticulum (ER) to the Golgi and mediates COPII vesicle formation at the transitional ER. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Feb 2013]
Function:
Defines endoplasmic reticulum exit sites (ERES) and is required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for normal transitional endoplasmic reticulum (tER) organization.
Subunit:
SEC16A and SEC16B are each present in multiple copies in a heteromeric complex. Interacts with SEC23A.
Subcellular Location:
Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Note=SAR1A activity is required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation.
Tissue Specificity:
Ubiquitous. Expressed at higher levels in the pancreas.
Similarity:
Belongs to the SEC16 family.
SWISS:
O15027
Gene ID:
9919
Database links:
Entrez Gene: 9919 Human
Omim: 612854 Human
SwissProt: O15027 Human
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