The protein encoded by this gene is a member of the SEC22 family of vesicle trafficking proteins. It seems to complex with SNARE and it is thought to play a role in the ER-Golgi protein trafficking. This protein has strong similarity to Mus musculus and Cricetulus griseus proteins.[provided by RefSeq, Sep 2009]
Function:
SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.
Subunit:
Interacts with STX17 (By similarity). Component of two distinct SNARE complexes consisting of STX5, GOSR2/BOS1, BET1 and SEC22B or STX18, USE1L, BNIP1/SEC20L and SEC22B. YKT6 can probably replace SEC22B in either complex.
Subcellular Location:
Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type IV membrane protein (By similarity). Golgi apparatus membrane; Single-pass type IV membrane protein (By similarity). Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Similarity:
Belongs to the synaptobrevin family.
SWISS:
O75396
Gene ID:
9554
Database links:
Entrez Gene: 9554 Human
Entrez Gene: 424377 Chicken
Entrez Gene: 20333 Mouse
Entrez Gene: 310710 Rat
Omim: 604029 Human
SwissProt: O75396 Human
SwissProt: O08547 Mouse
SwissProt: Q4KM74 Rat
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