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Rabbit Anti-Secretory phospholipase A2 Type V antibody
This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Function:
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. This isozyme hydrolyzes more efficiently L-alpha-1-palmitoyl-2-oleoyl phosphatidylcholine than L-alpha-1-palmitoyl-2-arachidonyl phosphatidylcholine, L-alpha-1-palmitoyl-2-arachidonyl phosphatidylethanolamine, or L-alpha-1-stearoyl-2-arachidonyl phosphatidylinositol. May be involved in the production of lung surfactant, the remodeling or regulation of cardiac muscle.
Subcellular Location:
Secreted.
Tissue Specificity:
Heart, placenta and less abundantly, in lung.
Post-translational modifications:
This enzyme lacks one of the seven disulfide bonds found in similar PA2 proteins.
Similarity:
Belongs to the phospholipase A2 family.
SWISS:
P39877
Gene ID:
5322
Database links:
Entrez Gene: 5322 Human
Entrez Gene: 18784 Mouse
Entrez Gene: 29354 Rat
Omim: 601192 Human
SwissProt: P39877 Human
SwissProt: P97391 Mouse
SwissProt: P51433 Rat
Unigene: 319438 Human
Unigene: 23347 Mouse
Unigene: 20244 Rat
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