Selenoprotein M is widely expressed and expressed highly in the mammalian brain. It is localized to the perinuclear structures (Golgi/ER). A growing body of evidence relates selenium to cancer prevention, immune system function, male fertility, cardiovascular disorder, control of the aging and neurodiseases process. Selenoproteins are thought to be responsible for the majority of these biomedical effects of selenium. Approximately 17 selenoproteins have been identified until now. Although the function of many selenoproteins are unknown, some play important roles in antioxidant mechanisms. It has been also implicated in the regulation of signaling pathways through catalysis of thiol/disulfide exchange. The roles of Selenoprotein M have not been clearly identified until present time.
Function:
May function as a thiol-disulfide oxidoreductase that participates in disulfide bond formation.
Subcellular Location:
Cytoplasm; perinuclear region. Endoplasmic reticulum Probable. Golgi apparatus Probable. Note: Localized to perinuclear structures corresponding to Golgi and endoplasmic reticulum.
Similarity:
Belongs to the selenoprotein M/SEP15 family.
SWISS:
Q8WWX9
Gene ID:
140606
Database links:
Entrez Gene: 140606 Human
Entrez Gene: 114679 Mouse
Entrez Gene: 498398 Rat
Omim: 610918 Human
SwissProt: Q8WWX9 Human
SwissProt: Q8VHC3 Mouse
Unigene: 55940 Human
Unigene: 34046 Mouse
Unigene: 8166 Rat
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