Home
>
Product
>
Antibody
>
Rabbit Anti-Semenogelin I/CT103 antibody
The protein encoded by this gene is the predominant protein in semen. The encoded secreted protein is involved in the formation of a gel matrix that encases ejaculated spermatozoa. The prostate-specific antigen (PSA) protease processes this protein into smaller peptides, with each possibly having a separate function. The proteolysis process breaks down the gel matrix and allows the spermatozoa to move more freely. The antimicrobial peptide SgI-29 is an antimicrobial peptide with antibacterial activity. [provided by RefSeq, Nov 2014]
Function:
Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA.
Alpha-inhibin-92 and alpha-inhibin-31, derived from the proteolytic degradation of semenogelin, inhibit the secretion of pituitary follicle-stimulating hormone.
Subcellular Location:
Secreted.
Tissue Specificity:
Seminal vesicle.
Post-translational modifications:
Transglutaminase substrate.
Rapidly cleaved after ejaculation by KLK3/PSA, resulting in liquefaction of the semen coagulum and the progressive release of motile spermatozoa.
Similarity:
Belongs to the semenogelin family.
SWISS:
P04279
Gene ID:
1286
Database links:
Entrez Gene: 1286 Human
Entrez Gene: 20944 Mouse
Entrez Gene: 25013 Rat
Omim: 182140 Human
SwissProt: P04279 Human
Unigene: 1968 Human
|
|
