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Rabbit Anti-CACNG6 antibody
Voltage-dependent calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of two known gamma subunit proteins. This particular gamma subunit is an integral membrane protein that is thought to stabilize the calcium channel in an inactive (closed) state. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members that function as transmembrane AMPA receptor regulatory proteins (TARPs). Alternative splicing results in multiple transcript variants. Variants in this gene have been associated with aspirin-intolerant asthma. [provided by RefSeq, Dec 2010]
Function:
Thought to stabilize the calcium channel in an inactivated (closed) state.
Subunit:
The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma.
Subcellular Location:
Plasma membrane
Similarity:
Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
SWISS:
Q9BXT2
Gene ID:
59285
Database links:
Entrez Gene: 59285 Human
Entrez Gene: 54378 Mouse
Entrez Gene: 140727 Rat
Omim: 606898 Human
SwissProt: Q9BXT2 Human
SwissProt: Q8VHW3 Mouse
SwissProt: Q8VHW7 Rat
Unigene: 91033 Rat
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