The gene is a member of the syntaxin family. The encoded protein is targeted to the apical membrane of epithelial cells where it forms clusters and is important in establishing and maintaining polarity necessary for protein trafficking involving vesicle fusion and exocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Function:
Potentially involved in docking of synaptic vesicles at presynaptic active zones.
Subcellular Location:
Membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}.
Similarity:
Belongs to the syntaxin family. {ECO:0000305}.
Contains 1 t-SNARE coiled-coil homology domain.
SWISS:
Q13277
Gene ID:
1369
Database links:
Entrez Gene: 1369 Human
Entrez Gene: 20908 Mouse
Entrez Gene: 8362 Rat
Omim: 600876 Human
SwissProt: Q13277 Human
SwissProt: Q64704 Mouse
SwissProt: Q08849 Rat
Unigene: 36711 Human
Unigene: 272264 Mouse
Unigene: 10951 Rat
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