NgR3 is a 441 amino acid protein that belongs to the Nogo receptor family. Localized to the cell membrane, NgR3 contains 8 LRR (leucine-rich) repeats. NgR3 is predominantly expressed in brain, where it localizes to the surface of neurons, but is also found at lower levels in lung, placenta, kidney, mammary gland, skeletal muscle, spleen and salivary gland. NgR3 is thought to play a role in the regulation of axonal regeneration and plasticity in the adult central nervous system. The gene that encodes NgR3 maps to human chromosome 17, which makes up over 2.5% of the human genome with about 81 million bases encoding over 1,200 genes.
Function:
RTN4RL1 may play a role in regulating axonal regeneration and plasticity in the adult central nervous system.
Subcellular Location:
Cell membrane; Lipid-anchor, GPI-anchor. Note: Localized to the surface of neurons, including axons
Tissue Specificity:
Predominantly expressed in brain. Expressed at lower levels in kidney, lung, mammary gland, placenta, salivary gland, skeletal muscle and spleen.
Similarity:
Belongs to the Nogo receptor family.
Contains 8 LRR (leucine-rich) repeats.
Contains 1 LRRCT domain.
Contains 1 LRRNT domain.
SWISS:
Q86UN2
Gene ID:
146760
Database links:
Entrez Gene: 146760 Human
Entrez Gene: 237847 Mouse
Entrez Gene: 303311 Rat
Omim: 610461 Human
SwissProt: Q86UN2 Human
SwissProt: Q8K0S5 Mouse
SwissProt: Q80WD0 Rat
Unigene: Human
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