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Rabbit Anti-phospho-Thymidine Kinase 1 (Ser13) antibody
Thymidine Kinase (TK1) is a highly conserved phosphotransferase that is present in most living cells. Thymidine Kinase catalyzes the phosphorylation reaction: deoxythymidine + ATP = deoxythymidine 5'-phosphate + ADP; it is thus involved in the reaction chain to introduce deoxythymidine into the DNA. Thymidine kinase is required for the action of many antiviral drugs, such as azidothymidine (AZT), and is is also used to select hybridoma cell lines in the production of monoclonal antibodies. Thymidine Kinase has many clinical applications as it is only present in anticipation of cell division. Because of this, Thymidine Kinase can be used as a proliferation marker in the diagnosis, treatment, and follow-up of malignant diseases, especially hematological malignancies. Thymidine Kinase may be observed as a monomer, dimer, trimer or tetramer.
Subcellular Location:
Cytoplasm.
Post-translational modifications:
Phosphorylated on Ser-13 in mitosis.
Similarity:
Belongs to the thymidine kinase family.
SWISS:
P04183
Gene ID:
7083
Database links:
Entrez Gene: 7083 Human
Entrez Gene: 21877 Mouse
Entrez Gene: 24834 Rat
Omim: 188300 Human
SwissProt: P04183 Human
SwissProt: P04184 Mouse
SwissProt: P27158 Rat
Unigene: 515122 Human
Unigene: 2661 Mouse
Unigene: 195325 Rat
Unigene: 216486 Rat
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