This gene encodes subunit 3 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 3 interacts with subunit 1 through its amino-terminus while the zinc finger domain of subunit 3 plays a role in its binding to the 15S U2 snRNP. This gene has a pseudogene on chromosome 20. [provided by RefSeq, Jul 2008]
Function:
Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex.
Subunit:
Identified in the spliceosome C complex. Component of splicing factor SF3A which is composed of three subunits; SF3A3/SAP61, SF3A2/SAP62, SF3A1/SAP114. SF3A associates with the splicing factor SF3B and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP). Interacts with SF3A1, through its N-terminal region.
Subcellular Location:
Nucleus speckle.
Tissue Specificity:
Ubiquitous.
Similarity:
Belongs to the SF3A3 family.
SWISS:
Q12874
Gene ID:
10946
Database links:
Entrez Gene: 419608 Chicken
Entrez Gene: 523250 Cow
Entrez Gene: 475326 Dog
Entrez Gene: 10946 Human
Entrez Gene: 75062 Mouse
Entrez Gene: 100512288 Pig
Entrez Gene: 313583 Rat
Entrez Gene: 495359 Xenopus laevis
Entrez Gene: 446168 Zebrafish
Omim: 605596 Human
SwissProt: Q12874 Human
SwissProt: Q9D554 Mouse
Unigene: 77897 Human
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