This gene belongs to the pyrroline-5-carboxylate reductase family. The encoded mitochondrial protein catalyzes the conversion of pyrroline-5-carboxylate to proline, which is the last step in proline biosynthesis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]
Function:
Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Detected in erythrocytes (at protein level).
Similarity:
Belongs to the pyrroline-5-carboxylate reductase family.
SWISS:
Q96C36
Gene ID:
29920
Database links:
Entrez Gene: 504987 Cow
Entrez Gene: 29920 Human
Entrez Gene: 69051 Mouse
Entrez Gene: 100172597 Orangutan
Entrez Gene: 312864 Rat
SwissProt: Q17QJ7 Cow
SwissProt: Q4R6W7 Cynomolgus Monkey
SwissProt: Q96C36 Human
SwissProt: Q922Q4 Mouse
SwissProt: Q5RAQ3 Orangutan
SwissProt: Q6AY23 Rat
Unigene: 654718 Human
Unigene: 27436 Mouse
Unigene: 137266 Rat
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