This gene is a member of the Rab family of GTPases that are involved in regulation of membrane traffic. The encoded protein contains an N-terminal EF-hand domain, a coiled-coil motif and a SLCterminal Rab domain. A potential role as tumor suppressor has been indicated for this gene. [provided by RefSeq, Nov 2012]
Function:
Binds predominantly GDP, and also GTP.
Subcellular Location:
Cytoplasm, perinuclear region.
Tissue Specificity:
Down-regulated in cutaneous melanoma cells but not in breast cancer cells.
Similarity:
Belongs to the small GTPase superfamily. Rab family.
SWISS:
Q8IZ41
Gene ID:
158158
Database links:
Entrez Gene: 158158 Human
Entrez Gene: 242505 Mouse
Omim: 611344 Human
SwissProt: Q8IZ41 Human
SwissProt: Q5RI75 Mouse
Unigene: 657750 Human
Unigene: 487185 Mouse
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