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Rabbit Anti-phospho-RASGRP3 (Thr133) antibody
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]
Function:
Guanine nucleotide exchange factor (GEF) for Ras and Rap1.
Similarity:
Belongs to the RASGRP family.
Contains 2 EF-hand domains.
Contains 1 N-terminal Ras-GEF domain.
Contains 1 phorbol-ester/DAG-type zinc finger.
Contains 1 Ras-GEF domain.
SWISS:
Q8IV61
Gene ID:
25780
Database links:
Entrez Gene: 25780 Human
Entrez Gene: 48168 Mouse
Omim: 609531 Human
SwissProt: Q8IV61 Human
Unigene: 143674 Human
Unigene: 329203 Mouse
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