Rabbit Anti-Endophilin II antibody

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SH3 containing Grb 2 like 1 protein; Endophilin II; CNSA1; EEN; EEN fusion partner of MLL; Endophilin-2; Endophilin-A2; Extra 11 19 leukemia fusion gene; Extra eleven-nineteen leukemia fusion gene protein; Fusion partner of MLL; MGC111371; SH3 co

Cat:

SL19747R

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human Endophilin II:31-130/368

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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This gene encodes a member of the endophilin family of Src homology 3 domain-containing proteins. The encoded protein is involved in endocytosis and may also play a role in the cell cycle. Overexpression of this gene may play a role in leukemogenesis, and the encoded protein has been implicated in acute myeloid leukemia as a fusion partner of the myeloid-lymphoid leukemia protein. Pseudogenes of this gene are located on the long arm of chromosomes 11 and 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

Function:
Implicated in endocytosis. May recruit other proteins to membranes with high curvature.

Subcellular Location:
Cytoplasm. Early endosome membrane. Associated with postsynaptic endosomes in hippocampal neurons.

Tissue Specificity:
Ubiquitous. Higher expression in pancreas, placenta, prostate, testis and uterus.

DISEASE:
Note=In some cases of acute leukemia, a translocation results in the formation of a MLL-EEN fusion gene.

Similarity:
Belongs to the endophilin family.
Contains 1 BAR domain.
Contains 1 SH3 domain.

SWISS:
Q99961

Gene ID:
6455

Database links:

Entrez Gene: 512719 Cow

Entrez Gene: 6455 Human

Entrez Gene: 20405 Mouse

Entrez Gene: 81922 Rat

Omim: 601768 Human

SwissProt: Q2KJA1 Cow

SwissProt: Q99961 Human

SwissProt: Q62419 Mouse

SwissProt: O35964 Rat

Unigene: 97616 Human

Unigene: 1773 Mouse

Unigene: 8762 Rat

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