This gene encodes a C2H2-type zinc finger protein, which may function as a transcription factor. This gene also contains long CAG trinucleotide repeats that encode consecutive glutamine residues. The protein appears to bind and regulate the promoters of the extracellular matrix genes MMP1, MMP3, MMP7 and COL1A1. Studies in mouse suggest that nuclear matrix transcription factors (NP/NMP4) may be part of a general mechanical pathway that couples cell construction and function during extracellular matrix remodeling. Alternative splicing results in multiple transcript variants. Recurrent rearrangements of this gene with the Ewing's sarcoma gene, EWSR1 on chromosome 22, or with the TAF15 gene on chromosome 17, or with the TCF3 (E2A) gene on chromosome 19, have been observed in acute leukemia. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Apr 2011]
Function:
Transcription factor that binds the consensus DNA sequence [GC]AAAAA. Seems to bind and regulate the promoters of MMP1, MMP3, MMP7 and COL1A1.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 8 C2H2-type zinc fingers.
SWISS:
Q8TF68
Gene ID:
171017
Database links:
Entrez Gene: 53007 Cow
Entrez Gene: 486723 Dog
Entrez Gene: 100726713 Guinea pig
Entrez Gene: 100059879 Horse
Entrez Gene: 171017 Human
Entrez Gene: 261960 Mouse
Entrez Gene: 100516975 Pig
Entrez Gene: 100341607 Rabbit
Entrez Gene: 171018 Rat
Omim: 609951 Human
SwissProt: Q8TF68 Human
SwissProt: Q9EQJ4 Rat
Unigene: 103315 Human
Unigene: 708126 Human
Unigene: 714839 Human
Unigene: 9637 Rat
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