Rabbit Anti-RBM35B/ESRP2 antibody

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Epithelial splicing regulatory protein 2; ESRP 2; ESRP2; ESRP2_HUMAN; FLJ21918; FLJ22248; RBM35B; RNA binding motif protein 35A; RNA binding motif protein 35B; RNA binding protein 35B; RNA-binding motif protein 35B; RNA-binding protein 35B.

Cat:

SL19772R

Species Reactivity：

(predicted: Human,Mouse,Rat,Cow,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human RBM35B/ESRP2:21-120/727

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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ESPR2 is an epithelial cell-type-specific splicing regulator (Warzecha et al., 2009 [PubMed 19285943]).[supplied by OMIM, Aug 2009]

Function:
mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.

Subcellular Location:
Nucleus.

Tissue Specificity:
Epithelial cell-specific.

Similarity:
Belongs to the ESRP family.
Contains 3 RRM (RNA recognition motif) domains.

SWISS:
Q9H6T0

Gene ID:
80004

Database links:

Entrez Gene: 510878 Cow

Entrez Gene: 80004 Human

Entrez Gene: 77411 Mouse

Entrez Gene: 307810 Rat

Omim: 612960 Human

SwissProt: Q9H6T0 Human

SwissProt: Q8K0G8 Mouse

SwissProt: B2RYJ8 Rat

Unigene: 436585 Human

Unigene: 592053 Human

Unigene: 183003 Mouse

Unigene: 137974 Rat

Unigene: 231924 Rat

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