This gene encodes a member of the RNA recognition motif family of RNA-binding proteins. The RNA recognition motif is between 80-100 amino acids in length and family members contain one to four copies of the motif. The RNA recognition motif consists of two short stretches of conserved sequence, as well as a few highly conserved hydrophobic residues. The encoded protein has a single, putative RNA recognition motif in its N-terminus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]
Function:
Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their SLCterminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins. Binds to poly(A) RNA.
Subcellular Location:
Nucleus. Cytoplasm.
Tissue Specificity:
Ubiquitously expressed, at various levels depending on the isoform and the tissue.
Similarity:
Contains 1 RRM (RNA recognition motif) domain.
SWISS:
Q93062
Gene ID:
11030
Database links:
Entrez Gene: 428738 Chicken
Entrez Gene: 614417 Cow
Entrez Gene: 11030 Human
Entrez Gene: 19663 Mouse
Entrez Gene: 498642 Rat
Omim: 601558 Human
SwissProt: Q9W6I1 Chicken
SwissProt: Q93062 Human
SwissProt: Q9WVB0 Mouse
Unigene: 334587 Human
Unigene: 323997 Mouse
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