Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet. [provided by RefSeq, Jul 2008]
Function:
High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-5 carbon atoms. The stoichiometry is probably 3 Na(+) for 1 divalent succinate.
Subcellular Location:
Cell membrane.
Tissue Specificity:
Expression is highest in kidney. Detected in placenta, brain, liver and pancreas.
Similarity:
Belongs to the SLC13A transporter (TC 2.A.47) family. NADC subfamily.
SWISS:
Q8WWT9
Gene ID:
64849
Database links:
Entrez Gene: 526291 Cow
Entrez Gene: 485910 Dog
Entrez Gene: 64849 Human
Entrez Gene: 114644 Mouse
Entrez Gene: 100738810 Pig
Entrez Gene: 100355238 Rabbit
Entrez Gene: 64846 Rat
Omim: 606411 Human
SwissProt: Q8WWT9 Human
SwissProt: Q91Y63 Mouse
SwissProt: Q9Z0Z5 Rat
Unigene: 655498 Human
Unigene: 250738 Mouse
Unigene: 3587 Rat
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