This gene encodes a protein belonging to the solute carrier family 13 group of proteins. This family member is a sodium-dependent citrate cotransporter that may regulate metabolic processes. Mutations in this gene cause early infantile epileptic encephalopathy 25. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Function:
High-affinity sodium/citrate cotransporter that mediates citrate entry into cells. The transport process is electrogenic; it is the trivalent form of citrate rather than the divalent form that is recognized as a substrate. May facilitate the utilization of circulating citrate for the generation of metabolic energy and for the synthesis of fatty acids and cholesterol.
Subcellular Location:
Membrane.
Tissue Specificity:
Expressed most predominantly in the liver, with moderate expression detectable in the brain and testis.
Similarity:
Belongs to the SLC13A transporter (TC 2.A.47) family. NADC subfamily.
SWISS:
Q86YT5
Gene ID:
284111
Database links:
Entrez Gene: 284111 Human
Entrez Gene: 237831 Mouse
Omim: 608305 Human
SwissProt: Q86YT5 Human
SwissProt: Q67BT3 Mouse
Unigene: 399496 Human
Unigene: 340778 Mouse
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