Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton linked monocarboxylate transporter (MCT) family, which has been designated solute carrier family 16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found.
Function:
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Similarity:
Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
SWISS:
O15374
Gene ID:
9122
Database links:
Entrez Gene: 9122 Human
Entrez Gene: 229699 Mouse
Entrez Gene: 295356 Rat
Omim: 603878 Human
SwissProt: O15374 Human
SwissProt: Q8R0M8 Mouse
Unigene: 351306 Human
Unigene: 38384 Mouse
Unigene: 72489 Rat
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