Home
>
Product
>
Antibody
>
Rabbit Anti-SLC19A1 antibody
SLC19A1 (Solute Carrier Family 19 (Folate Transporter), Member 1) is a Protein Coding gene. Diseases associated with SLC19A1 include placental choriocarcinoma and thiamine-responsive megaloblastic anemia syndrome. Among its related pathways are Cell Cycle, Mitotic and Metabolism. GO annotations related to this gene include oxidoreductase activity and folic acid transporter activity. An important paralog of this gene is SLC19A2.
Function:
Transporter for the intake of folate. Uptake of folate in human placental choriocarcinoma cells occurs by a novel mechanism called potocytosis which functionally couples three components, namely the folate receptor, the folate transporter, and a SLVtype H(+)-pump.
Subcellular Location:
Membrane.
Tissue Specificity:
Placenta, liver, and to a much smaller extent, in lung.
Post-translational modifications:
Heavily glycosylated.
Similarity:
Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
SWISS:
P4188
Gene ID:
6573
Database links:
Entrez Gene: 6573 Human
Entrez Gene: 29723 Rat
Omim: 600424 Human
SwissProt: P4188 Human
SwissProt: Q62866 Rat
Unigene: 84190 Human
Unigene: 9042 Rat
|
|