The protein encoded by this gene is a sodium-phosphate symporter that absorbs phosphate from interstitial fluid for use in cellular functions such as metabolism, signal transduction, and nucleic acid and lipid synthesis. The encoded protein is also a retroviral receptor, causing human cells to be susceptible to infection by gibbon ape leukemia virus, simian sarcoma-associated virus, feline leukemia virus subgroup B, and 10A1 murine leukemia virus.[provided by RefSeq, Mar 2011]
Function:
Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLSLVB) as well as 10A1 murine leukemia virus (10A1 MLV).
Subcellular Location:
Membrane.
Tissue Specificity:
Ubiquitously expressed.
Similarity:
Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
SWISS:
Q8WUM9
Gene ID:
6574
Database links:
Entrez Gene: 493789 Cat
Entrez Gene: 514255 Cow
Entrez Gene: 6574 Human
Entrez Gene: 100173250 Orangutan
Entrez Gene: 81826 Rat
Omim: 137570 Human
SwissProt: O97596 Cat
SwissProt: Q8WUM9 Human
SwissProt: Q5R9L5 Orangutan
SwissProt: Q9JJP0 Rat
Unigene: 187946 Human
Unigene: 732750 Human
Unigene: 162702 Rat
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