Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A14 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Mar 2008]
Function:
May be able to transport iron (By similarity). Acts as a zinc-influx transporter.
Subunit:
Homotrimer.
Subcellular Location:
Cell membrane. Cell projection > lamellipodium. Localized to the plasma membrane and also found colocalized with F-actin concentrated on lamellipodiae.
Tissue Specificity:
Ubiquitously expressed, with increased expression in liver, pancreas, fetal liver, thyroid gland, left and right ventricle, right atrium and fetal heart. Weakly expressed in spleen, thymus, and peripheral blood leukocytes.
Similarity:
Belongs to the ZIP transporter (TC 2.A.5) family.
SWISS:
Q15043
Gene ID:
23516
Database links:
Entrez Gene: 412844 Chimpanzee
Entrez Gene: 23516 Human
Entrez Gene: 100387296 Marmoset (common)
Entrez Gene: 213053 Mouse
Entrez Gene: 100172692 Orangutan
Omim: 608736 Human
SwissProt: Q15043 Human
SwissProt: Q75N73 Mouse
SwissProt: Q5RAB7 Orangutan
Unigene: 491232 Human
Unigene: 270647 Mouse
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