The protein encoded by this gene belongs to the ZIP family of zinc transporters that transport zinc into cells from outside, and play a crucial role in controlling intracellular zinc levels. Zinc is an essential cofactor for many enzymes and proteins involved in gene transcription, growth, development and differentiation. Mutations in this gene have been associated with autosomal dominant high myopia (MYP24). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]
Function:
May play a role in polarized cells by carrying out serosal-to-mucosal zinc transport. Seems to play a central role in controlling organismal zinc status.
Subcellular Location:
Basolateral cell membrane.
Tissue Specificity:
Expressed in liver, kidney, pancreas, small intestine, colon, spleen, fetal liver and fetal kidney.
Post-translational modifications:
Glycosylated.
Similarity:
Belongs to the ZIP transporter (TC 2.A.5) family.
SWISS:
Q6ZMH5
Gene ID:
283375
Database links:
Entrez Gene: 283375 Human
Entrez Gene: 14402 Mouse
Entrez Gene: 362812 Rat
GenBank: NM_173596 Human
Omim: 608730 Human
SwissProt: Q6ZMH5 Human
SwissProt: Q9D856 Mouse
Unigene: 591018 Human
Unigene: 22983 Mouse
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