The product of this gene is part of a protein complex that regulates the endocytosis of growth factor receptors. The encoded protein directly interacts with a GTPase activating protein that functions downstream of the small G protein Ral. Its expression can negatively affect receptor internalization and inhibit growth factor signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function:
Involved in growth factor signaling through its influence on the Ral signaling pathway.
Subunit:
Interacts with ASAP1 and this complex can bind paxillin. May form a ternary complex with RALBP1 and ASAP1 (By similarity). Interacts with RALBP1 and GRB2. Binding to RALBP1 does not affect the Ral-binding activity of the latter. It can form a ternary complex with activated Ral and RALBP1. Binds EPN1.
Subcellular Location:
Cytoplasmic.
Tissue Specificity:
Expressed at high levels in the cerebrum, cerebellum, lung, kidney, and testis. Weakly expressed in the kidney. Relatively highly expressed in androgen-dependent as compared to androgen-independent prostate cancer cell lines and xenografts. Isoform 2 is down-regulated during progression of prostate cancer.
Post-translational modifications:
EGF stimulates phosphorylation on Tyr-residues and induces complex formation with EGF receptor through an adapter protein such as GRB2.
Similarity:
Contains 1 EF-hand domain.
Contains 2 EH domains.
SWISS:
Q8NFH8
Gene ID:
9185
Database links:
Entrez Gene: 526887 Cow
Entrez Gene: 100056954 Horse
Entrez Gene: 9185 Human
Entrez Gene: 100353871 Rabbit
Entrez Gene: 363466 Rat
Omim: 300317 Human
SwissProt: Q8NFH8 Human
Unigene: 186810 Human
Unigene: 207682 Rat
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