REXO1 or Elongin A-binding protein 1 (EloA-BP1) is an exonuclease domain-containing protein that can bind to Elongin. The Elongin complex stimulates the rate of transcription elongation by RNA polymerase II by suppressing the transient pausing of the polymerase at many sites along the DNA template. REXO1 is composed of 1221 amino acids and its mRNA is ubiquitously expressed. EloA-BP1 is capable of binding not only the NH(2)-terminal approximately 120 amino acid region of Elongin A, but also that of SII. Although REXO1 had no detectable effect on the rate of transcription elongation in vitro, it may play some role in the regulation of elongation in vivo.
Function:
Seems to have no detectable effect on transcription elongation in vitro.
Subunit:
Interacts with TCEA2 and TCEB3.
Subcellular Location:
Nuclear
Similarity:
Belongs to the REXO1/REXO3 family.
Contains 1 exonuclease domain.
SWISS:
Q8N1G1
Gene ID:
57455
Database links:
Entrez Gene: 57455 Human
Omim: 609614 Human
SwissProt: Q8N1G1 Human
Unigene: 192477 Human
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