Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Associates specifically with the activated forms of the G protein subunits G(i)-alpha and G(z)-alpha but fails to interact with the structurally and functionally distinct G(s)-alpha subunit. Activity on G(z)-alpha is inhibited by palmitoylation of the G-protein.
Post-translational modifications:
Isoform 3 is phosphorylated on Ser-16.
Similarity:
Contains 1 RGS domain.
SWISS:
O43665
Gene ID:
6001
Database links:
Entrez Gene: 614550 Cow
Entrez Gene: 6001 Human
Entrez Gene: 67865 Mouse
Entrez Gene: 448968 Pig
Entrez Gene: 54290 Rat
Omim: 602856 Human
SwissProt: Q2KHW7 Cow
SwissProt: O43665 Human
SwissProt: Q9CQE5 Mouse
SwissProt: P41966 Rat
Unigene: 50240 Human
Unigene: 18635 Mouse
Unigene: 23957 Rat
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