This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]
Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.
Isoform 5: Behaves as a cell cycle-dependent transcriptional repressor, promoting inhibition of S-phase DNA synthesis.
Subunit:
Interacts with GNAI1, GNAI2 and GNAI3; the interactions are GDP-dependent.
Subcellular Location:
Nuclear
Tissue Specificity:
Isoform 3 is brain specific.
Similarity:
Contains 1 GoLoco domain.
Contains 1 PDZ (DHR) domain.
Contains 1 PID domain.
Contains 2 RBD (Ras-binding) domains.
Contains 1 RGS domain.
SWISS:
O14924
Gene ID:
6002
Database links:
Entrez Gene: 6002 Human
Entrez Gene: 71729 Mouse
Entrez Gene: 54292 Rat
Omim: 602512 Human
SwissProt: O14924 Human
SwissProt: Q8CGE9 Mouse
SwissProt: O08774 Rat
Unigene: 196208 Mouse
Unigene: 9796 Rat
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