The protein encoded by this gene belongs to the 'regulator of G protein signaling' family. It inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade. [provided by RefSeq, Jul 2008]
Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. May play a role in regulating the kinetics of signaling in the phototransduction cascade.
Tissue Specificity:
Abundantly expressed in retina with lower levels of expression in most other tissues.
Post-translational modifications:
Palmitoylated on Cys-2 and/or Cys-12.
Phosphorylation on Tyr-168 upon EGFR stimulation. Enhanced GTPase accelerating (GAP) activity on G(i)-alpha.
Similarity:
Contains 1 RGS domain.
SWISS:
O15492
Gene ID:
6004
Database links:
Entrez Gene: 282035 Cow
Entrez Gene: 6004 Human
Entrez Gene: 19734 Mouse
Entrez Gene: 397544 Pig
Entrez Gene: 72857 Rat
Omim: 602514 Human
SwissProt: O46471 Cow
SwissProt: O15492 Human
SwissProt: P97428 Mouse
SwissProt: P56700 Rat
Unigene: 413297 Human
Unigene: 181709 Mouse
Unigene: 202892 Rat
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