This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Expressed in peripheral leukocytes, bone marrow, platelet, spleen and fetal liver.
Similarity:
Contains 1 RGS domain.
SWISS:
Q9NS28
Gene ID:
6887
Database links:
Entrez Gene: 6887 Human
Entrez Gene: 64214 Mouse
Entrez Gene: 289076 Rat
Omim: 607192 Human
SwissProt: Q9NS28 Human
SwissProt: Q99PG4 Mouse
SwissProt: Q4L0E8 Rat
Unigene: 88890 Human
Unigene: 253927 Mouse
Unigene: 202353 Rat
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