This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP and GGL domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Many alternatively spliced transcript variants encoding different isoforms with long or short N-terminal domains, complete or incomplete GGL domains, and distinct SLCterminal domains, have been described for this gene, however, the full-length nature of some of these variants is not known.[provided by RefSeq, Mar 2011]
Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/Gbeta5 dimer.
Subunit:
Heterodimer with Gbeta5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5 (By similarity).
Subcellular Location:
Cytoplasm. Membrane.
Similarity:
Contains 1 DEP domain.
Contains 1 G protein gamma domain.
Contains 1 RGS domain.
SWISS:
P49758
Gene ID:
9628
Database links:
Entrez Gene: 9628 Human
Entrez Gene: 50779 Mouse
Entrez Gene: 54295 Rat
Omim: 603894 Human
SwissProt: P49758 Human
SwissProt: Q9Z2H2 Mouse
SwissProt: P41961 Rat
Unigene: 509872 Human
Unigene: 153013 Mouse
Unigene: 199537 Rat
Unigene: 207298 Rat
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