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Rabbit Anti-RHBDF1 antibody
RHBDF1 is a seven-transmembrane protein with a long N-terminal cytoplasmic extension that comprises half of the polypeptide sequence, and is found in the endoplasmic reticulum and Golgi, but not on the cell surface. RHBDF1 has a pivotal role in sustaining growth signals in epithelial cancer cells and thus may serve as a therapeutic target for treating epithelial cancers.
Function:
Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration.
Subunit:
Homodimer, or homooligomer. Interacts with TGFA and HBEGF. Interacts with EGF; may retain EGF in the endoplasmic reticulum and regulates its degradation through the endoplasmic reticulum-associated degradation (ERAD).
Subcellular Location:
Endoplasmic reticulum and Golgi Apparatus.
Tissue Specificity:
Highly expressed in cerebellum, cerebrum, heart, skeletal muscle, placenta, pancreatic islet and testis. Detected at lower levels in colon, kidney, small intestine and lung.
Similarity:
Belongs to the peptidase S54 family.
SWISS:
Q96CC6
Gene ID:
64285
Database links:
Entrez Gene: 64285 Human
Entrez Gene: 13650 Mouse
Entrez Gene: 303008 Rat
SwissProt: Q96CC6 Human
SwissProt: Q6PIX5 Mouse
SwissProt: Q499S9 Rat
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