Ras homolog, or Rho, proteins interact with protein kinases and may serve as targets for activated GTPase. They play a critical role in muscle differentiation. The protein encoded by this gene binds GTP and is a member of the small GTPase superfamily. It is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Function:
Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Participates in reorganization of actin cytoskeleton.
Subunit:
Interacts (in GTP-bound form) with DIAPH2 isoform 3, DAPK3, FILIP1 and WHAMM. Interacts with PAK7/PAK5. Interacts (independent of GTP-loaded status) with ANKFY1.
Subcellular Location:
Cell membrane.
Tissue Specificity:
Heart, placenta, liver, skeletal muscle, and pancreas and, with weaker intensity, in several other tissues.
Similarity:
Belongs to the small GTPase superfamily. Rho family.
SWISS:
O00212
Gene ID:
29984
Database links:
Entrez Gene: 29984 Human
Entrez Gene: 11854 Mouse
Entrez Gene: 293660 Rat
Omim: 605781 Human
SwissProt: O00212 Human
SwissProt: P97348 Mouse
Unigene: 15114 Human
Unigene: 27701 Mouse
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