This gene encodes a subunit of the polymerase associated factor (PAF1) complex. The PAF1 complex interacts with RNA polymerase II and plays a role in transcription elongation as well as histone modifications including ubiquitylation and methylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
Function:
The mammalian PAF1 complex is a multifunctional complex. The PAF1 complex interacts with RNA polymerase II and may be involved in both initiation and elongation, and in histone methylation and RNA processing. Has oncogenic activity in vivo and in vitro.
Subcellular Location:
Nucleus. Punctuate distribution throughout the nucleus except in nucleoli and the perinuclear chromatin.
Similarity:
Belongs to the PAF1 family.
SWISS:
Q8N7H5
Gene ID:
54623
Database links:
Entrez Gene: 54623 Human
Entrez Gene: 54624 Mouse
Entrez Gene: 361531 Rat
Entrez Gene: 446278 Xenopus laevis
Omim: 610506 Human
SwissProt: Q8N7H5 Human
SwissProt: Q8K2T8 Mouse
SwissProt: Q4V886 Rat
SwissProt: A2BD83 Xenopus laevis
Unigene: 466714 Human
Unigene: 7916 Mouse
Unigene: 161558 Rat
Unigene: 29705 Xenopus laevis
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