This gene encodes a deadenylase that functions as the catalytic subunit of the polyadenylate binding protein dependent poly(A) nuclease complex. The encoded protein is a magnesium dependent 3' to 5' exoribonuclease that is involved in the degradation of cytoplasmic mRNAs. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Function:
Functions in cytoplasmic mRNA decay. As part of the Pan nuclease complex, shortens poly(A) tails of RNA when the poly(A) stretch is bound by polyadenylate-binding protein.
Subcellular Location:
Cytoplasm. Nucleus. Shuttles between nucleus and cytoplasm.
Similarity:
Belongs to the peptidase C19 family.
PAN2 subfamily.
Contains 1 exonuclease domain.
SWISS:
Q504Q3
Gene ID:
9924
Database links:
Entrez Gene: 9924 Human
Entrez Gene: 103135 Mouse
Entrez Gene: 408200 Rat
SwissProt: Q504Q3 Human
SwissProt: Q8BGF7 Mouse
SwissProt: Q6IE70 Rat
Unigene: 273397 Human
Unigene: 244183 Mouse
Unigene: 9091 Rat
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