This gene encodes a member of the solute carrier family 6 protein family which transports neutral amino acids. The encoded protein is thought to play a role in neuronal amino acid transport (PMID: 16185194) and may be associated with major depression (PMID: 21521612). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Function:
Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particulary leucine, valine and isoleucine and methionine. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent.
Subcellular Location:
Membrane.
Tissue Specificity:
Almost exclusively expressed in the brain.
Similarity:
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
SLC6A15 subfamily.
SWISS:
Q9H2J7
Gene ID:
55117
Database links:
Entrez Gene: 55117 Human
Entrez Gene: 103098 Mouse
Entrez Gene: 282712 Rat
Omim: 607971 Human
SwissProt: Q9H2J7 Human
SwissProt: Q8BG16 Mouse
SwissProt: Q08469 Rat
Unigene: 44424 Human
Unigene: 451688 Mouse
Unigene: 9716 Rat
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