The protein encoded by this gene is a cationic amino acid transporter and a member of the APC (amino acid-polyamine-organocation) family of transporters. The encoded membrane protein is responsible for the cellular uptake of arginine, lysine and ornithine. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Function:
Low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine). Plays a regulatory role in classical or alternative activation of macrophages.
Subcellular Location:
Membrane.
Tissue Specificity:
Expressed at high levels in the skeletal muscle, placenta and ovary. Expressed at intermediate levels in the liver and pancreas and at low levels in the kidney and heart.
Similarity:
Belongs to the amino acid-polyamine-organocation (APC) superfamily.
Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
SWISS:
P52569
Gene ID:
6542
Database links:
Clone ID: 100037298 Pig
Entrez Gene: 740548 Chimpanzee
Entrez Gene: 538708 Cow
Entrez Gene: 6542 Human
Entrez Gene: 11988 Mouse
Entrez Gene: 100433164 Orangutan
Entrez Gene: 64554 Rat
Omim: 601872 Human
SwissProt: P52569 Human
SwissProt: P18581 Mouse
SwissProt: A8I499 Pig
SwissProt: B5D5N9 Rat
Unigene: 448520 Human
Unigene: 4676 Mouse
Unigene: 48707 Rat
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