Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCDC (EC 4.1.1.36), one of the last enzymes in this pathway, converts phosphopantothenoylcysteine to 4-prime-phosphopantetheine (Daugherty et al., 2002 [PubMed 11923312]).[supplied by OMIM, Mar 2008]
Function:
Necessary for the biosynthesis of coenzyme A. Catalyzes the decarboxylation of 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine.
Similarity:
Belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
SWISS:
Q96CD2
Gene ID:
60490
Database links:
Entrez Gene: 60490 Human
Entrez Gene: 66812 Mouse
Omim: 609854 Human
SwissProt: Q96CD2 Human
SwissProt: Q8BZB2 Mouse
Unigene: 458922 Human
Unigene: 250508 Mouse
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