The protein encoded by this gene is a phosphoprotein that may upregulate the PDGFA-stimulated growth of fibroblasts and also downregulate the mitogenicity of PDGFB. The encoded protein in rodents has been shown to bind PDGFA with a low affinity. [provided by RefSeq, Dec 2010]
Function:
Enhances PDGFA-stimulated cell growth in fibroblasts, but inhibits the mitogenic effect of PDGFB.
Similarity:
Belongs to the PDAP1 family.
SWISS:
Q13442
Gene ID:
11333
Database links:
Entrez Gene: 100139074 Cow
Entrez Gene: 489861 Dog
Entrez Gene: 100063675 Horse
Entrez Gene: 11333 Human
Entrez Gene: 231887 Mouse
Entrez Gene: 100352808 Rabbit
Entrez Gene: 64527 Rat
Omim: 607075 Human
SwissProt: Q13442 Human
SwissProt: Q3UHX2 Mouse
SwissProt: Q62785 Rat
Unigene: 632296 Human
Unigene: 188851 Mouse
Unigene: 6158 Rat
|
|