This gene encodes a member of the prefoldin alpha subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. The encoded protein may also repress the transcriptional activity of the proto-oncogene c-Myc. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Function:
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
Tissue Specificity:
Highly expressed in pancreas and skeletal muscle and moderately in other tissues.
Similarity:
Belongs to the prefoldin subunit alpha family.
SWISS:
Q99471
Gene ID:
5204
Database links:
Entrez Gene: 5204 Human
Entrez Gene: 56612 Mouse
Entrez Gene: 300257 Rat
Omim: 604899 Human
SwissProt: Q99471 Human
SwissProt: Q9WU28 Mouse
Unigene: 655327 Human
Unigene: 158264 Mouse
Unigene: 3401 Rat
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